Source Naturals SAMe is a stable, bioavailable form of S-adenosyl-L-methionine. These tablets are enteric coated and blister packed to prevent breakdown and inactivation of the ingredients. Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. It is important to the joints because of its critical role in cartilage formation. Studies also show that SAMe helps support a positive outlook. It is able to cross the blood-brain barrier where it affects the synthesis and activation of various proteins, such as neurotransmitters. SAMe is known as a "methyl donor." This means that it works by giving up a piece of itself a methyl group consisting of one carbon and three hydrogen atoms to other molecules. Methylation plays a part in many critical cellular functions. SAMe is present in every living cell in the body. However, levels of SAMe tend to decline with age.Supplement Facts for 400 mg TabletServing Size 1 tablets Amount%DVSAMe S-adenosyl-L-methionine 400 mgfrom 800 mg of SAMe disulfate tosylateOther Ingredients cellulose, hydroxypropyl methylcellulose phthalate, titanium dioxide, mannitol, stearic acid, triacetin, sodium starch glycolate, modified cellulose gum, citric acid, silica, and yellow ochre.Warning If you are pregnant, breastfeeding or are taking antidepressant medication, consult your physician before using this product. Take this product under medical supervision if you have bipolar disorder. In a small percentage of people this product may cause nausea which tends to subside with long-term use. Do not use if either tamper-evident seal is broken or missing. Keep out of the reach of children.Suggested Use One tablet, one to three times daily. Take tablets on an empty stomach.